@charset "UTF-8";

/* alphabet-and-numbers: serif */
body div#wrapper-contents {
	font-family: "Times New Roman", -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol";
}

img {
	vertical-align:bottom;
}

/* セリフ体 */
.serif {
	font-family: serif;
}

div#contents p#go-index {
	margin-bottom: 1em;
	font-size: 0.8em;
	margin-left: 0;
}


/* 上に戻る */
div#contents p.return-top {
	clear: both;
	margin-top: 1em;
	margin-bottom: 1em;
	text-align: center;
	font-size: 0.9em;
	line-height: 1;
}

div#contents p.return-top img {
	border :0 none;
	margin-right :0.5em;
	vertical-align :baseline;
}
div#contents p.return-top a {
	display: block;
	width: 100%;
	padding-left: .5em;
}
div#contents p.return-top a:link,
div#contents p.return-top a:visited {
	background-color: #fff;
	text-decoration: none;
}
div#contents p.return-top a:hover,
div#contents p.return-top a:active,
div#contents p.return-top a:focus {
	background-color: #f5f5f5;
	color: #f00;
}

div#contents p,
div#contents dl,
div#contents ul,
div#contents table {
	margin-left: 5em;
	margin-right: 5em;
}

/********************************
INDEX
*********************************/

div#contents .index {
	margin-bottom: 2em;
	padding: 1em;
	border: 1px solid #ccc;
	font-size: 0.9em;
}
div#contents .index h2 {
	color: #f00;
	font-size: 1.2em;
}

div#contents .index ul {
	margin-left: 5em;
}
div#contents .index li {
	list-style: none;
	margin: 0;
}
div#contents .index li a {
	display: block;
	padding: .5em 0 .5em 14px;
	text-decoration: underline;
	background: url(images/liststyleBall.jpg) no-repeat left calc(.5em * 1.42857143 + .5em - 5px);
}
div#contents .index li a:hover,
div#contents .index li a:focus {
	color: #f00;
	text-decoration: underline;
	background-color: #F1F4FF;
}
div#contents .index li a.active {
	text-decoration: none;
	color: #000;
	background-image: url(images/liststyleBall_cr.jpg);
}

/*******  **********/

h2 {
	margin-top: 1em;
	margin-bottom:0.75em;
	padding: 0.2em 0.5em;
	background-color:#f5f5f5;
	border:1px solid #dedede;
	border-top:1px solid #eee;
	border-left:1px solid #eee;
	color: #0e6698;
	font-size: 1.2em;
	font-weight:bold;
	line-height: 1;
}

h3 {
	margin-top: 1em;
	margin-left: 3em;
	margin-bottom: 1.5em;
	color: #0e6698;
	font-size: 1.2em;
	text-align: left;
	font-weight:bold;
}

ol li {
	margin-left: 5em;
	margin-bottom: 1em;
}
div.section ul li {
	list-style: circle;
}
div.section p img {
	padding-top: 1em;
	padding-bottom: 1em;
}
.center {
	text-align: center;
}
.center img{margin-left: auto;
	margin-right: auto;
	}

.left {
	text-align: left;
}
.r {
	text-align: right;
}
img.border {
	border: 1px solid #ccc;
}
img.border2 {
	padding: 1em;
	border: 1px solid #ccc;
}

/* 定義リスト */
dl {
	padding: 1em;
}
dl dt {
	font-weight: bold;
	margin: .5em 0;
}
dl dd {
	padding: 0 0 0 2em;
}
h3 + dl {
	padding-top: 0;
}

/******* 有害事象 **********/
table.damage-list {
	width: auto;
	margin: 2em auto;
	border-top: 2px solid #999;
	border-bottom: 2px solid #999;
	border-right: 2px solid #fff;
}

table.damage-list thead {
	border-bottom: 2px solid #999;
	background-color: #dee7f0;
}
	
table.damage-list tbody tr.even ,
table.damage-list tbody tr:nth-child(2n) {
	background: #eaeff7;
}
table.damage-list tr.total {
	border-bottom: 2px solid #999;
}
table.damage-list tr.subgroup th ,
table.damage-list tr.subgroup td {
	border-top: 2px solid #999;
}
table.damage-list td,
table.damage-list th {
	border-top: 1px solid #ccc;
	border-bottom: 1px solid #ccc;
	border-right: 1px solid #ccc;
	padding: 0.2em 1em;
}
table.damage-list th {
	font-weight: bold;
}
table.damage-list td {
	text-align: center;
}
table.damage-list th.title {
	text-align: left;
}
table.damage-list th.caution {
	color: #ff1493;
}
table.damage-list th.case ,
table.damage-list td.r {
	text-align: right;
}
table.damage-list th.case span {
	font-weight: normal;
	font-size: 0.95em;
}

table.damage-list th.case-left ,
table.damage-list td.left {
	text-align: left;
}
table.damage-list .addtext {
	position: relative;
	text-align: left;
	line-height: 1em;
}
table.damage-list .addtext span {
	position: absolute;
	display: block;
	padding-left: 1em;
	left: 100%;
	top: -1.5em;
	width: 10em;
}

table.damage-list .nowrap {
	white-space: nowrap;
}
span.italic {
	font-style: italic;
}
span.normal {
	font-weight: normal;
}
p.indnt {
	text-indent: -1em;
	padding-left: 1em;
}


/******* 参考 **********/
table.sample-list {
	width: auto;
	margin: 2em auto;
	border-top: 2px solid #999;
	border-bottom: 2px solid #999;
	border-right: 2px solid #fff;
}
table.sample-list thead {
	border-bottom: 2px solid #999;
	background-color: #dee7f0;
}
	
table.sample-list tbody tr.even ,
table.sample-list tbody tr:nth-child(2n) {
	background: #eaeff7;
}
table.sample-list tr.total {
	border-bottom: 2px solid #999;
	font-weight: bold;
}
table.sample-list tr.subgroup th ,
table.sample-list tr.subgroup td {
	border-top: 2px solid #999;
}
table.sample-list td,
table.sample-list th {
	border-top: 1px solid #ccc;
	border-bottom: 1px solid #ccc;
	border-right: 1px solid #ccc;
	padding: 0.2em 1em;
}
table.sample-list th {
	font-weight: bold;
}
table.sample-list td {
	text-align: center;
}
table.sample-list th.title {
	text-align: left;
}
table.sample-list th.caution {
	color: #ff1493;
}
table.sample-list th.case ,
table.sample-list td.r {
	text-align: right;
}
table.sample-list th.case span {
	font-weight: normal;
	font-size: 0.95em;
}

table.sample-list th.case-left ,
table.sample-list td.left {
	text-align: left;
}
table.sample-list .addtext {
	position: relative;
	text-align: left;
	line-height: 1em;
}
table.sample-list .addtext span {
	position: absolute;
	display: block;
	padding-left: 1em;
	left: 100%;
	top: -1.5em;
	width: 10em;
}

table.sample-list .nowrap {
	white-space: nowrap;
}




/* 画像横並び ACTG5142 */
div.column2 {
	margin: 0 auto;
	width: 800px;
	overflow: hidden;
}
div.column2 div {
	float: left;
	width: 400px;
	text-align: center;
}
div.column2 div img {
	border: 1px solid #ccc;
}
div.column2 div h3,
div#contents div.column2 div p {
	margin-left: 0;
}
/* グラフ線の色 */
/* 間欠治療群 */
span.kanketsu {
	color: #f33;
	font-weight: bold;
}
/* 治療継続群 */
span.keizoku {
	color: #33f;
	font-weight: bold;
}

/* ボタン */
p.show_button {
	text-align: left;
}
p.show_button button {
	background-color:#f5f5f5;
	border-top:1px solid #eee;
	border-left:1px solid #eee;
	border-bottom:1px solid #dedede;
	border-right:1px solid #dedede;
	border-radius: 3px;
	-moz-border-radius: 3px;
	-webkit-border-radius: 3px;
}

/* 複数タイトル */
.plural-title1 {
	padding: 1em 0;
}
.plural-title1 h3 {
	margin-top: 0;
	margin-bottom: 0;
	text-align: left;
	color: #0e6698;
}

/* カラー */
.steelblue {
	color: #0e6698;
}

/* 補足 */
ul.supplementation {
	text-align: center;
}
ul.supplementation li {
	display: inline;
}

/* 左５文字アキ */
.left5 {
	margin-left: 5em;
}
.top1 {
	margin-top: 1em;
}

/* 参照 */
.ref {
	margin-top: 1em;
	color: #6661fe;
}

/* 縦書き */
.text-vertical {
	writing-mode: vertical-rl;
	text-orientation: sideways;
	white-space: nowrap;
}

.style-normal {
	font-weight: normal;
}

div#contents p.release {
	margin-right: 0;
	text-align: right;
	font-size: 0.9em;
	color: #666;
}

/* 追加 */
table.twocolumn{margin-left:auto!important;
	margin-right: auto!important;
	width: 100%;
	}
table.twocolumn caption{font-weight: bold;
	color: #333;
	font-size: 1.1em;
}

/* フレックスコンテナ */
.flex-container {
  display: -webkit-flex; /* Safari */
  display: flex;
  -webkit-flex-wrap: wrap; /* Safari */
  flex-wrap:         wrap;
  /* 下揃え */
  -webkit-align-items: flex-end; /* Safari */
  align-items:         flex-end;
}
.flex-container img{max-width: 100%;}


/*  */
@media screen and (max-width: 991px){
	.col-12 + .col-12{margin-top: 40px;}
	.col-12 + .col-12 table{margin-top: 0;}
}